Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins
نویسندگان
چکیده
منابع مشابه
Dynamic strategies for target-site search by DNA-binding proteins.
Gene regulatory proteins find their target sites on DNA remarkably quickly; the experimental binding rate for lac repressor is orders-of-magnitude higher than predicted by free diffusion alone. It has been proposed that nonspecific binding aids the search by allowing proteins to slide and hop along DNA. We develop a reaction-diffusion theory of protein translocation that accounts for transport ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2021
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2021.01.039